Àá½Ã¸¸ ±â´Ù·Á ÁÖ¼¼¿ä. ·ÎµùÁßÀÔ´Ï´Ù.
KMID : 0359319910310040441
Korean Journal of Veterinary Research
1991 Volume.31 No. 4 p.441 ~ p.447
Effect of levamisole , selenium and tocopherol on the lymphocyte blastogenesis and production of antibody in Korean native goat



Abstract
In this study, effect of levamisole, selenium and tocopherol on the lymphocyte blastogenesis and antibody production in Korean native goat were evaluated in vitro and in vivo.
Lymphocyte blastogenesis of goat blood increased significantly (p<0.01 and p<0.05) when the cells were treated in vitro with levamisole at the concentration of 50¡­500§¶/§¢, with selenium at the concentration of 0.062¡­1.0§¶ and with tocopherol nt the concentration on 12.5§¶. Increased lymphocyte blastogenesis was detected from 2 to 24 hours after oral administration of levamisole (2.5§·/§¸ of body weight). After 7 days, increased mitogenic response of lymphocytes was not detected.
Meanwhile increased blastogenesis of lymphocyte from goats given the selenium-tocopherol mixture (selenium 100§¶-tocopherol 200IU/head/day) was detected from 10 days after feeding, and the tendency continued throughout the entire experimental period.
When immune responses of goats against PPD were subjected to test by ELISA, the mean IgG titers of levamisolc group (1 : 1,800) and selenium-tocopherol group (1 : 960) were higher than that of control group (1 : 600) at 2 weeks after lst inoculation.
At 3 weeks after lst inoculation and 1 week after 2nd inoculation, the significant (p<0.05) differences in IgG titers were detected among the three groups. The mean IgG titers of levamisole group, selenium-tocopherol group and control at that time were 1 : 20, 480, 1 : 5, 120 and 1 : 2,640, respectively.
The IgG production of levamisole group was significantly (p<0.01) higher than that of control group.
KEYWORD
FullTexts / Linksout information
Listed journal information
ÇмúÁøÈïÀç´Ü(KCI)